0586 An observational retrospective study of the prevalence of comorbid postural orthostatic tachycardia syndrome (POTS) in narcolepsy

Abstract Introduction Postural orthostatic tachycardia syndrome (POTS) is a clinical of dysautonomia associated with an excessive increase in heart rate following shift to standing posture. As 2019, POTS has prevalence 1-3 million (0.3-0.9%) the United States. Narcolepsy chronic neurologic condition persistent hypersomnolence irrespective total sleep time that also REM-sleep dissociative features (i.e., cataplexy, paralysis, sleep-related hallucinations). In recent years, viral infections have been established as trigger for both conditions. Methods A manual chart review was performed records from 11/1/2020 12/20/2022. The overall clinic population narcolepsy identified by searching electronic medical record ICD-10 codes G47.411 (narcolepsy type 1 [NT1]), and G47.419 2 [NT2]). past history these charts then searched identify patients separate all clinic. Results Of 1,433 population, 207 (NT1=73, 35.3%; NT2=134, 64.7%) 24 were identified. co-morbid 8.7% (18, 95% CI 5.2-13.4%); those POTS, 75% had (95% 53.3-90.2%). Co-morbid higher NT1 (13, 17.8% 9.8-28.5%) than NT2 (5, 3.7% 1.2-8.5%). significantly (1.26% 0.75-1.98%) general population. Conclusion especially subgroup. Clinicians should consider screening narcolepsy, vice versa. Further studies are warranted explore etiology POTS. Support (if any) N/A